Octaplex 500IU injection is a hemostatic that belongs to the group of medicines called clotting factors. It contains the human prothrombin complex which is composed of vitamin K-dependent blood coagulation factors II, VII, IX, and X. It is used to treat and prevent acute major bleeding caused by certain medicines called vitamin K antagonists (warfarin). It is also indicated in people born with low levels of vitamin K-dependent coagulation factors II and X.  It is used when a purified specific clotting factor product is unavailable. Do not take Octaplex 500IU injection  if you are allergic to heparin and any one of the ingredients in the medicine. Inform your physician if you have IgA (immunoglobulin A) deficiency with known antibodies against IgA. Tell your physician if you have a history of heart problems, liver diseases or if you are going to have any surgery before initiating the treatment.  This medicine may increase your risk of thrombosis (blood clots); notify your physician immediately if you face any signs and symptoms of thrombosis, such as limb or abdomen swelling or pain, chest pain, drop in blood pressure, shortness of breath, loss of sensation or motor power, altered consciousness, vision or speech disturbances, confusion, and fever. Limited information is available regarding the use of Octaplex 500IU injection in children and adolescents. The most common side effects are headache, nausea, vomiting, decreased blood pressure, and anemia. Human prothrombin complex is made from human blood; hence it may carry a risk of transmitting infectious agents. Discuss the risks and benefits with your doctor before receiving this medicine