Akynzeo Injection is an anti-emetic medication containing a fixed-dose combination of two active ingredients, such as fosnetupitant and palonosetron. Fosetupitant is a neurokinin-1 (NK-1) receptor antagonist, while palonosetron is a 5-HT3 receptor antagonist.  This medication is used to prevent chemotherapy-induced nausea and vomiting (CINV). It is prescribed to help cancer patients to better tolerate their chemotherapy treatments by reducing the likelihood of these distressing side effects and is also used to control postoperative nausea and vomiting. The common side effects that are likely to occur with this medicine are hives, swollen face, breathing trouble, and chest pain. Inform your healthcare provider if these side effects concern you or persist for longer than usual. If you have liver problems or renal impairment, discuss this with your physician. Dosing adjustments may be necessary in such cases. There is a potential risk of serotonin syndrome when Akynzeo Injection is combined with other serotonergic medications. Serotonin syndrome can cause symptoms such as agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, and coordination problems. Inform your physician about all medications, including antidepressants and other serotonergic drugs, that you are taking. The safety and efficacy of Akynzeo Injection in pediatric patients have not been established. It is primarily intended for use in adults. It is unsafe to administer this drug to pregnant women because it may cause harm to the baby. Please consult your doctor before taking this medicine. It is unclear whether this drug passes into breast milk for breastfeeding women, and consulting a doctor for guidance would be a better choice.